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Welcome to TrialSphere

TrialSphere Clinical Research (formerly MD First Research Chandler) was established in 2017. Since then, we have focused on neurological studies, especially cognitive impairment research. Over time, we have also expanded into more therapeutic areas.

Today, our private Chandler, Arizona site supports studies in cognitive impairment and other chronic conditions, including:

  • Migraines
  • Neuropathy
  • Diabetes
  • Chronic pain
  • Other health conditions

Through impactful clinical research, our team helps improve patient care. For example, our work has supported treatments such as Droxidopa (Northera®), Rimegepant (Nurtec ODT®), Lecanemab-irmb (Leqembi®), and Donanemab-azbt (Kisunla®). As a result, more patients have access to promising new therapies.

Above all, our Physicians and Nurse Practitioners work closely with sponsors and patients. As a result, we improve the study experience and help drive medical progress.

Patient-First Research

We keep patients at the center of every study. Therefore, we offer individuals the chance to participate in clinical studies that may provide early access to promising new therapies.

TrialSphere is led by Dr. Hemant K. Pandey, M.D., a board-certified neurologist, cognitive impairment, and sleep specialist. With more than 20 years of experience, our team supports people living with neurological conditions and chronic illness.

In August 2024, we earned the Dementia Friendly Business Designation. Because of this commitment, we continue building a supportive and informed environment for those affected by cognitive impairment.

In affiliation with the Brain and Spine Center and Nuronz, we partner closely with sponsors and patients. As a result, our research remains rigorous, compassionate, and built to improve lives.

Mission

Advancing Medicine, Inspiring Tomorrow.

Vision

Redefining clinical research through patient-centered inclusion and integrity, accelerating breakthrough treatments for diverse communities

Our Site

Our Chandler location serves the Greater Phoenix area and surrounding communities. In addition, our site is:

  • Grounded in collaborative sponsor and provider partnerships, with the community at the center of every study
  • Committed to outreach that expands community awareness, education, and engagement in clinical research
  • Home to an on-site infusion suite supporting investigational therapies with comfort and safety
  • Dedicated to destigmatizing clinical research, building understanding and trust, and empowering participation in groundbreaking studies
Core Values

PRINCIPAL INVESTIGATOR

Dr. Hemant K. Pandey, M.D., is a local neurologist with significant contributions to clinical research and neurological science, dedicated to advancing Alzheimer’s care through compassionate practice and innovative research. With more than 20 years of experience in brain and nerve health, he leads several medical and research centers, including TrialSphere Clinical Research (formerly MD First Research Chandler), the Brain and Spine Center, and Nuronz.

He completed his neurology training at West Virginia University Hospital in Morgantown, West Virginia, graduating as Chief Resident, and went on to complete a fellowship in Electrophysiology encompassing Electromyography (EMG) and Electroencephalography (EEG) at the University of Texas Health Science Center MD Anderson Cancer Center in Houston, Texas. He is board certified in Neurology with subspecialty board certifications in Sleep Medicine, Vascular Neurology, and Clinical Neurophysiology, and is a member of the American Academy of Neurology.

With over two decades of research experience, Dr. Pandey has focused on Alzheimer’s disease in both early and advanced stages, migraine treatment and prevention, stroke, Parkinson’s disease, and multiple sclerosis. Since 2018, he has led Alzheimer’s studies that connect patients to leading research opportunities and emerging therapies while maintaining personalized, high-quality care. His work has helped shape new treatment paradigms and improve patient outcomes, bridging scientific discovery with everyday clinical practice.

Research Contributions:
Dr. Pandey has led numerous clinical studies advancing the understanding and treatment of neurological disorders and has served as principal investigator for over 30 studies. His research has contributed to new therapies and tools in practice, and he has authored and co-authored more than 20 scientific publications, including abstracts, posters, and peer-reviewed articles.

Leadership and Community Impact:
Dr. Pandey served as Stroke Director of the Stroke Program at Chandler Regional Medical Center and as a leader in the Mercy Gilbert Medical Center Stroke Program, strengthening local stroke care and emergency response systems. He also serves as a speaker and advisor for major pharmaceutical companies including Eli Lilly, Eisai, and Novo Nordisk, and advises plasma biomarker innovators C2N and Lucent AD, supporting earlier detection and more targeted treatment for Alzheimer’s disease. Actively engaged with local community organizations, he promotes brain health education and supports patients and families affected by neurological disorders.

Dr. Pandey is known for diagnosing and treating various forms of dementia and values patient support groups for the close connection they create with patients and loved ones navigating cognitive illness.

“To be able to be of service brings me joy—either as a neurologist, a scout dad, a teacher in Chinmaya, or as an Indian hosting festivities at home—and is something I feel privileged about,” he says.

Dr. Pandey

PRINCIPAL INVESTIGATOR

Dr. Rajiv Parikh, M.D., is a board-certified family medicine physician and clinical researcher with more than two decades of experience in patient care and clinical investigation. He brings extensive medical knowledge, steady clinical leadership, and a friendly, collaborative approach to the research setting, supporting high-quality studies that advance treatment options for diverse patient populations. Known for clear, tactful communication with both medical and non-medical teams, he handles sensitive patient information with the highest level of professionalism and integrity.

Dr. Parikh has served as a Principal and Sub-Investigator with MD First Research Chandler LLC since January 2019. His research background includes participation in multicenter clinical studies across a wide range of therapeutic areas, including major depressive disorder, type 2 diabetes, neurogenic orthostatic hypotension, vaccines for adolescents and young adults, chronic obstructive pulmonary disease, drug-resistant focal-onset epilepsy, and post-exposure prophylaxis for COVID-19. This breadth reflects his versatility as an investigator and his commitment to translating research into meaningful clinical impact.

In parallel with his research work, Dr. Parikh has led a private family practice in Tempe, Arizona since 2000, providing comprehensive, relationship-driven care across the lifespan. His clinical expertise includes family medicine and primary care with a strong focus on chronic conditions such as diabetes, hyperlipidemia, hypertension, obesity, anxiety and depression, and pediatrics, giving him a broad perspective that strengthens both participant safety and study quality. He is recognized for remaining composed under pressure, bridging cultural differences with ease, and building inclusive teams that support excellent research conduct.

Dr. Parikh completed residency training in both Family Medicine and Pediatrics at UC Irvine Medical Center in Irvine, California, following pediatric residency and internship training at Baroda Medical College and SSG Hospital in India, where he earned his Bachelor’s degree in medicine and surgery. He is affiliated with Banner Desert Medical Center and Banner Heart Hospital in Mesa, Arizona. Through his combined experience in community medicine and clinical research, Dr. Parikh plays a vital role in advancing studies that improve care today and shape the therapies of tomorrow.

Rajiv Parikh, M.D.

CLINICAL RESEARCH INVESTIGATOR

Jan Levine, RN, MSN, FNP-BC, is a neurology nurse practitioner and clinical research professional with 17 years experience caring for patients with complex neurological conditions and supporting high-quality clinical studies. She earned her Bachelor of Science in Nursing from Arizona State University and her Master of Science as a Family Nurse Practitioner from Grand Canyon University. Board-certified through the American Nurses Credentialing Center, she also maintains current training in Good Clinical Practice and Basic Life Support.

Jan’s clinical background includes nearly ten years at Phoenix Neurological Associates, where she diagnosed and treated patients in both hospital and outpatient settings, with an emphasis on headache and migraine disorders, stroke, peripheral neuropathy, multiple sclerosis, epilepsy, pain syndromes, and movement disorders. Her long-standing work in neurology is matched by deep experience in research operations, including participant recruitment, eligibility review and enrollment, clinical assessments, and careful monitoring and management of adverse events in alignment with study protocols.

From 2021 to 2024, Jan served as a Nurse Practitioner with CND Life Sciences, playing a primary role in synucleinopathy diagnostic research. She performed skin biopsy procedures according to approved protocols, ensured accurate data capture in electronic systems, and upheld the highest standards of ethics, subject safety, and regulatory compliance, including SOPs, OSHA requirements, GCP guidelines, and local regulations. Her recent scholarly focus centers on skin biopsy diagnostic testing for synucleinopathies such as Parkinson’s disease, Lewy body dementia, pure autonomic failure, multiple system atrophy, and REM sleep behavior disorder.

A respected contributor to the neurology community, Jan has presented at the American Academy of Neurology and published in medical journals. She brings a rare combination of clinical depth, procedural expertise, and research rigor to every study, helping ensure participants receive attentive care while advancing discoveries that improve neurological health.

Jan Levine, RN, MSN, FNP-BC

SUB-INVESTIGATOR

Simon Parkinson, MSN, ARNP, FNP-C, CNRN, is a board-certified nurse practitioner with training in family practice and neuroscience nursing, and long-standing experience in general neurology and neurosurgery. Raised in North Wales, he trained as a nurse in London and moved to Phoenix, Arizona in 1999 to work at the Barrow Neurologic Institute. He served there as an ICU staff nurse from 1999 to 2005 and later returned as a nurse practitioner from 2007 to 2011. He earned his BSc (Hons) in Nursing from Anglia Polytechnic University and completed his Master of Nursing and Family Nurse Practitioner training through the University of Phoenix.

Simon has practiced as a nurse practitioner in family medicine, neurosurgery, and neurology, developing strong clinical expertise in the care of patients with headaches and migraine prevention, neuropathy, neck and back pain, movement disorders, epilepsy, and Parkinson’s disease. He is experienced in performing EEGs and ambulatory EEGs, EMGs, botulinum toxin injections for migraine and cervical dystonia, Deep Brain Stimulation management for Parkinson’s patients, and Vagus Nerve Stimulation for refractory epilepsy. He holds board certification as a Family Nurse Practitioner, maintains Arizona licensure as an advanced nurse practitioner, and is a Certified Neuroscience Registered Nurse.

At the Brain and Spine Center, Simon has served as a nurse practitioner since 2012 and as Director of the Nurse Practitioner Program since 2015. He is also the founder and neuromodulation specialist at Electrocellz LLC. Since 2017, he has contributed to clinical research as a Sub-Investigator with TrialSphere Clinical Research (formerly MD First Research Chandler), supporting studies in Alzheimer’s disease, dementia-related agitation, migraine prevention, and relapsing-remitting multiple sclerosis, as well as completed studies including acute and preventive migraine therapies and post-surgical pain management.

With specialized research training and deep familiarity with neurological outcome measures and patient assessments, Simon brings precision, safety focus, and compassionate care to every study, helping advance therapies that improve life for patients and families affected by neurological disease.

Simon Parkinson, FNP-C, Sub-Investigator
TrialSphere Clinical Research Staff
  • Dr. Pandey presented at Central Arizona Aging Conference on September 25, 2025
  • Dr. Pandey at Friendship Village of Tempe July 14, 2025
  • Maricopa Senior Living Sponsor and Vendor on June 17, 2025
  • Jan Levine RN, MSN, FNP-BC presented at Pueblo Norte Senior Living followed by a Memory Screening Event on June 16, 2025
  • May 24, 2025 Ukulele Band Sponsor for Oakwood Creative Care's 50th Birthday Bash
  • May 22, 2025 Dr. Pandey presents at Indian Association
  • April 3, 2025 and May 12, 2025 Dr. Pandey presents at Successful Aging AZ Dementia Conference and Oakwood Creative Care - Dementia Hub
  • April 3, 2025 Dr. Pandey presents at Successful Aging AZ Dementia Conference
  • March 7, 2025 - March 29, 2025 Sponsor and Exhibitor with YMCA, Miles for Migraine, and Neighbors Who Care Play It Forward
  • All Things Senior Expo
  • Glory Days Senior Program Presentation
  • Glory Days Flyer
  • Lovin' Life and Aging Made Easier Expos
  • Anthem at Merrill Ranch
  • Memory Cafe Sun Lakes
  • Memory Cafe Flyer
  • Successful Aging AZ Dementia Conference
  • The Park at Copper Creek Town Hall
  • 2024 Holiday Party
  • Jan Levine, RN, MSN, FNP-BC presented "From Millennials to Gen-Z: ​The Evolution of Memory Testing & Dementia Care​" at The Park at Copper Creek on November 7, 2024
  • Walk to End Alzheimer's November 2, 2024
  • MD First Research Chandler Joins the 2nd Annual Pretty in Pink Luncheon to Support Bosom Buddies of AZ at The Park at Copper Creek in Chandler, AZ on October 17, 2024
  • Dr. Hemant K. Pandey, M.D., Presents "Alzheimer’s Disease (AD) ​is a Growing Healthcare Crisis​" at Friendship Village Tempe on October 3, 2024
  • Dr. Hemant K. Pandey, M.D., Presents "Alzheimer’s Disease (AD) ​is a Growing Healthcare Crisis​" at Friendship Village Tempe on October 3, 2024
  • Dr. Hemant K. Pandey, M.D. presented “New Parkinson Use of Biomarkers in Clinical Practice” at Page Family Practice in Tempe, Arizona on September 11, 2024.
  • Dr. Hemant K. Pandey, M.D. presented “New Parkinson Use of Biomarkers in Clinical Practice” at Page Family Practice in Tempe, Arizona on September 11, 2024.
  • Dr. Rajiv Parikh, M.D. Presented “Understanding and Managing Type 2 Diabetes and Neuropathy” at Oakwood Creative Care – Dementia Hub in Mesa, Arizona on September 12, 2024
  • Dr. Rajiv Parikh, M.D. Presented “Understanding and Managing Type 2 Diabetes and Neuropathy” at Oakwood Creative Care – Dementia Hub in Mesa, Arizona on September 12, 2024
  • Dr. Rajiv Parikh, M.D. Presented “Understanding and Managing Type 2 Diabetes and Neuropathy” at Oakwood Creative Care – Dementia Hub in Mesa, Arizona on September 12, 2024
  • Angela Rush, FNP-C, Investigator presented “Navigating Dementia: Practical Tips for Caregivers and Loved Ones” at Clarendale of Chandler in Chandler, Arizona on September 6, 2024.
  • Penny Kalscheur, Clinical Research Marketer, Presents MD First Research Chandler at Oak Street Health in Mesa, AZ on August 13, 2024, Joined by Local Healthcare Leaders
  • Angela Rush - Oakwood Creative Care Dementia Hub
  • Angela Rush, FNP-C, Principal and Sub-Investigator presented "Clinical Research" at Clarendale of Chandler in Chandler, Arizona on July 1, 2024.
  • Dr. Hemant K. Pandey, M.D. presented “Dementia: Can We Reduce the Risk?” at Clarendale of Chandler in Chandler, Arizona on June 3, 2024.
  • Dr. Rajiv Parikh, M.D. and Angela Rush, FNP-C, Principal and Sub-Investigator presented “Clinical Trials Relating to Alzheimer’s, Diabetes, Idiopathic REM Behavior Disorder Study (RBD), and more” on June 1, 2024 at the Health and Wellness/Women’s Day Out Expo held at DoubleTree by Hilton in Gilbert, Arizona.
  • Angela Rush, FNP-C, Principal and Sub-Investigator presented "Talking About Dementia" on May 22, 2024 at Hawthorn Court at Ahwatukee with Morning Star Lewis providing complimentary memory screenings.
  • Dr. Hemant K. Pandey, M.D. presented at the Neighbors Who Care Summer Speaker Series Session 1: “Preventing Diseases of the Brain through Better Health Habits“ held at The Park at Copper Creek in Chandler, Arizona on May 16, 2024.
  • Dr. Hemant K. Pandey, M.D. presented at the Neighbors Who Care Summer Speaker Series Session 1: “Preventing Diseases of the Brain through Better Health Habits“ held at The Park at Copper Creek in Chandler, Arizona on May 16, 2024.
  • MD First Research Chandler participates in the Clarendale of Chandler Wellness Expo in Chandler, Arizona on May 14, 2024.
  • Dr. Hemant K. Pandey, M.D. and Angela Rush, FNP-C, Principal and Sub-Investigator presented at Clarendale Chandler in Chandler, Arizona on May 6, 2024.
  • Dr. Hemant K. Pandey, M.D. and Angela Rush, FNP-C, Principal and Sub-Investigator presented at Clarendale Chandler in Chandler, Arizona on May 6, 2024.
  • Dr. Hemant K. Pandey, M.D. and Angela Rush, FNP-C, Principal and Sub-Investigator, presented ‘Latest Advances in Dementia’ at Parkland Memory Care in Chandler, Arizona on April 15, 2024.
  • Dr. Hemant K. Pandey, M.D. and Angela Rush, FNP-C, Principal and Sub-Investigator, presented ‘Latest Advances in Dementia’ at Parkland Memory Care in Chandler, Arizona on April 15, 2024.
  • Health and Wellness/Women's Day Out Expo on April 13, 2024 at the Mesa Convention Center.
  • Miles for Migraine Walk on March 9, 2024
  • Miles for Migraine Walk on March 9, 2024
  • Dementia Conference Hosted by Successful Aging AZ on February 29, 2024
  • Dementia Conference Hosted by Successful Aging AZ on February 29, 2024
  • Dementia Conference Hosted by Successful Aging AZ on February 29, 2024
  • Dr. Hemant K. Pandey featured in the June 2023 Chandler City Lifestyle Magazine.

We are a leading Arizona center for clinical research studies, conducting innovative work in dementia, migraines, neuropathy, and other neurological conditions.